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Rockefeller University Animal Technician, Systems Cancer Biology in New York, New York

Job: IRC25860

Description

Job Title Animal Technician, Systems Cancer Biology

Laboratory / Department Systems Cancer Biology

Department Description

Cancer remains a daunting problem despite decades of active research into its molecular causes. Such studies have predominantly focused on the earliest stages of cancer progression such as the formation of a cancer or genes involved in the growth of the primary tumor. In humans afflicted by cancer, the primary tumor is typically surgically resected or eliminated by radiation. Vast numbers of patients, nonetheless die of cancer as a result of metastasis, or the spread of cancer cells from the primary tumor site to distal organs. This process is in fact the overwhelming cause of death from cancer and its occurrence changes a patient's prognosis to incurable. Despite its vast clinical significance and inherently fascinating underlying biology, the metastatic program is poorly understood- both at the molecular level and at the cellular/tissue micro-environment levels. Our laboratory employs a multi-disciplinary approach involving molecular, biochemical, computational, imaging, and clinical association methods to characterize the critical regulatory pathways that mediate the steps of this process. By implanting human cancer cells obtained from patients with breast or colon cancer into recipient mice, we study and interfere with the various stages of metastasis. By comparing human cancer cells that are highly metastatic to those that fail to metastasize, we have uncovered a set of small RNA molecules (microRNAs) that suppress metastasis. Our future work is aimed at gaining a better understanding of the mechanisms by which these microRNAs block metastasis. Our hope is that a better understanding of this process will enhance our therapeutic arsenal against it.

Detailed Description

The Animal Technician will assist senior members of the laboratory with all aspects of animal work. Responsibilities include managing mouse colonies (i.e. weaning mouse pups and updating an electronic mouse cage census), genotyping transgenic mice, and performing basic surgery such as tumor cell injections and tumor resections. Will serve as a primary liaison between the lab and animal facility staff, and devote some time to basic laboratory maintenance under the supervision of the Laboratory Manager.

Job Requirements

High School diploma or equivalent required; Bachelor's degree and educational emphasis in biology, chemistry, or the life sciences preferred. Must be interested in and enthusiastic about working mouse models. Previous experience working with rodents, performing molecular biology techniques (tissue and DNA extraction and PCR), and working with mammalian cell culture is desirable. Excellent organization skills to handle multiple tasks at once, and strong written and oral communication skills required. Must be enthusiastic about learning, a team player, and have strong commitment and responsibility. Must have the ability to anticipate and execute beyond given tasks and responsibilities.

Additional Details

Will work with Biosafety level 2 hazards and rDNA.

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans

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